The E2 F transcription factors are essential for regulating the correct timing of activation of several genes whose products are implicated in cell proliferation and DNA replication.
Induction of S-phase entry by E2 F transcription factors depends on their nuclear localization Here, we describe the identification of a novel member of this family, which we refer to as E2 F-6. All five are key elements in transcriptional regulation of essential genes., and they can be divided into two functional groups, those that induce S-phase progression when overexpressed in quiescent cells ( E2Fs 1-3), and those that do not ( E2Fs 4-5). Five members of the E2 F family have been previously reported, namely E2 F1-5. E2 F-6 is a nuclear protein that can form heterodimers with the DP.The E2 F family of transcription factors are essential for the regulation of genes required for appropriate progression through the cell cycle.
Unlike E2Fs 1-5, E2 F-6 lacks a transactivation and a pocket protein binding domain, hence, forms a unique third group within the E2 F family. With E2Fs 1-5, especially within the DNA binding, heterodimerization and marked box domains. Here we.Į2 F-6: a novel member of the E2 F family is an inhibitor of E2 F-dependent transcription In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2 F transcription factors that control S-phase genes.
We discuss this feature as the possible onset of superconductivity originating from a phase separation in a small fraction of the sample in the vicinity of the magnetic transition.Ĭyclin E-induced S phase without activation of the pRb/ E2 F pathway In the pressure range Ëœ7.5 -11 GPa a remarkable downturn in resistivity, which resembles a superconducting transition, is observed below 15 K. The insulator-to-metal transformation observed at a pressure of Ëœ7 GPa is accompanied by a loss of magnetic ordering and an isostructural phase transition. Below Ëœ7 GPa, Tl F e1.6 S e2 is an antiferromagnetically ordered semiconductor with a ThC r2 S i2 -type structure. The crystal structure, magnetic ordering, and electrical resistivity of Tl F e1.6 S e2 were studied at high pressures. Pressure-induced magnetic collapse and metallization of Tl F e1.6 S e2
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